Proton pump inhibitors (PPI’s) heartburn drugs include Nexium, Priolsec and Prevacid, have been found to increase the risk of developing kidney disease. These popular drugs are taken for the treatment of heartburn, indigestion, gastritis and acid reflux. The manufactures of PPIs have had knowledge for nearly a decade that these drugs can cause kidney disease and injury, including acute interstitial nephritis. In December 2014 the manufactures changed their packaging and labels warning of an association with PPIs and interstitial nephritis, diagnosed by kidney biopsy. This packaging and label change did not include a general warning regarding both acute and chronic kidney disease even though two recently published studies confirmed a significant increased risk to patients taking PPIs.